Mesothelioma Diagnosis – Understanding the Process


Laboratory and imaging studies to determine the nature of mesothelioma is the intended use and the judiciary. The diagnostic test results will eventually result in disease staging and prognosis.

Currently, the reference is used to detect malignant mesothelioma is a biochemical marker serum levels of soluble mesothelin. 2,00 nmol / L cut - of the value of the reference limit and 95% specificity and sensitivity of 64%. Emerging biochemical marker for diagnosis of malignant mesotheliomas megakaryocyte potentiating factor (MPF) is. This compound is soluble mesothelin the same source. Megakaryocyte potentiating factor 12,38 ng / 68% limit of sensitivity of the diagnosis of Miley as a reference. Malignant mesothelioma of the test combination of both biochemical markers do not show an increase in energy.
clinical studies
Pleural fluid findings between patients with malignant mesothelioma usually show a distinct profile. This is a high white cell count (1000 leukocytes / liter), elevated protein, normal lactate dehydrogenase levels, and has some erithrosaits. Pleural fluid was also Cytologic examination revealed malignant cells in some. However, both these tests, inspections of non-malignant mesothelioma.

Tissue biopsy in diagnosing malignant pleural mesothelioma using Thoracoscopy or pleuroscopy remains the gold standard. Histologic staining techniques, the correct meaning of the right side of a large contribution. More per patient to predict the impact of the disease.

It was lung cancer, especially adenocarcinoma to distinguish different types of malignant mesothelioma is required. Management of each disease and to predict the stark differences that suggest that the right decision. Adenocarcinomas of small words, but electron microscopy revealed that, under the malignant mesothelioma, showing long microvilli. Profile of these two disease entities that differ from their reaction to various stains. But the positive results for adenocarcinoma of the malignant mesothelioma, carcinoembryonic antigen is periodic acid Schiff (PAS), mucicarmine, (CEA), and displays the results in staining with Leu M1. On the other hand malignant mesothelioma vimentin, cytokeratin, and calretinin for staining shows positive results in. (SMRP) protein is associated with circulating levels of serum mesothelin in patients with malignant mesothelioma have been identified as elevated in 84%. Patients with lung cancer, but only 2% with the same rise.

Malignant mesothelioma, reactive mesothelial cells can also be done separately from the simple effusions. In this case, fluorescence in situ hybridization (FISH) plays a major role. Malignant mesothelioma is indicative of chromosomal aberrations, such as chromosome 22 by FISH to detect the loss of a copy, and some of the naming of an abnormal chromosome 6, 79% of sensing range. Fish is also a positive predictive value 100% and a negative predictive value of 72% of mesothelioma of the diagnosis.

For example, chest radiographs, CT scans, MRIs, and PET imaging studies that demonstrate the use of the disease, the value of the final stage. Evaluation of pulmonary functions, including the ability to broadcast to the patient prior to surgery. Pharmacologic agents used for stress testing is a good way to rule out the existence of silent myocardial ischemia.

Stage of the TNM classification of malignant mesothelioma of staging one of the most widely used by doctors. Stage I through IV. Disease is confined to the parietal pleura of the capsule is scheduled for Phase I, is completely resectable, and not the presence of adenopathy. Cut the tiles in the tumor to detect positive or intrapleural adenopathy, or both in the presence of Phase II is scheduled for when. Disease of the chest wall, midiyastinam, heart, diaphragm, peritoneum or pleura infiltrated by outside the lymph When Phase III is scheduled for later. Present with distant metastases, stage IV is assigned. Selection of treatment is tailored according to stage of disease, the disease.

Male, 75 more than the old age, the presence of chest pain, weight loss, most of the plate let count, high WBC count, low hemoglobin, LDH level of 500 IU: the presence of the following factors are generally of a poor prognosis in patients with malignant mesothelioma Spelling / L, and the epitheloid histology.


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